Real Madrid suffered a shock 1-0 home defeat to Real Betis on Wednesday as an inspired performance from their former goalkeeper Antonio Adan and a stoppage-time winner from Antonio Sanabria stunned the Liga champions.
A summary of Tuesday's Champions League Round of 16, Second Leg, matches.
Real Madrid beat Leganes 2-1 in La Liga on Saturday after coach Zinedine Zidane heavily rotated his side in preparation for Tuesday's Champions League semi-final second leg against Bayern Munich, including leaving out top-scorer Cristiano Ronaldo.
Real Madrid extended their unbeaten run to 25 matches and rejoined Barcelona and Atletico Madrid at the top of La Liga when Jese, Karim Benzema and Luka Modric scored in a 3-0 win at Getafe on Sunday.
A second half double from Karim Benzema helped Real Madrid to a 4-1 victory at Girona on Sunday and maintain their perfect La Liga start in the post-Cristiano Ronaldo era.
Real Madrid coach Carlo Ancelotti hailed his "extraordinary" players after they set a Spanish record for consecutive victories of 19 thanks to a 4-0 success at home to Ludogorets.
Barcelona suffered a shock 1-0 LaLiga defeat at Real Sociedad on Sunday that ended their seven-match winning streak in all competitions.
Here, Reuters Sport highlights five reasons why last season's double winners have collapsed.
Real were smarting from a surprise 1-1 draw at struggling Elche in their last match and were missing captain Sergio Ramos, who was out with a stomach bug.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
'This was why Juventus brought me here. To help do things that they have never done before'
Atletico Madrid coach Diego Simeone praised his team's spirit after knocking holders Barcelona out of the Champions League.
Real Madrid opened a two-point lead over Villarreal at the top of La Liga when Cristiano Ronaldo set a club scoring record in a 3-0 stroll at home to Levante on Saturday.
The Polish striker will miss games against Espanyol, Atletico Madrid and Getafe when LaLiga resumes after the World Cup.
Real went top with one game to play after thrashing Atletico Madrid 4-0 while rivals Sociedad slipped to a 3-2 defeat at Celta Vigo.
Cristiano Ronaldo answered his critics with a hat-trick as Real Madid came from behind to win 4-1 at Alaves and provisionally go three points clear at the top of La Liga.
Manchester United were mistakenly drawn with Villarreal, even though both teams faced each other in the group stage while the Premier League side's ball was not added to the bowl as a potential opponent for Atletico Madrid.
Spain goalkeeper Iker Casillas left Real Madrid on Saturday after 16 seasons as an iconic figure at the Bernabeu.
La Liga champions Barcelona stayed on the heels of leaders Real Madrid by coasting to a 3-0 home win over Athletic Bilbao on Saturday as Lionel Messi became the club's top scorer from free kicks.
Real Madrid's Javier Hernandez struck twice as they came from behind to beat Celta Vigo 4-2 away and keep the pressure on Barcelona at the top of La Liga on Sunday.
Atletico Madrid delayed Barcelona's La Liga title celebrations by beating Valencia 3-2 at home in an entertaining game on Wednesday at a sparsely attended Wanda Metropolitano stadium.
Chelsea's Champions League semi-final defeat by Atletico Madrid hinged on a pivotal second-half minute and the expertise of a young goalkeeper on loan from the Premier League club to the Spanish side, Jose Mourinho said on Wednesday.
Morata to stay on loan at Juventus for another season
Spain and Liverpool legend Luis Garcia believes that Indian football can touch global heights if the players are given exposure to different leagues abroad and nourish young talents and coaches methodically.
Real Madrid saw off a stirring Chelsea fightback to book their place in the Champions League semi-finals following a 3-2 defeat after extra time in a scintillating second leg at the Santiago Bernabeu on Tuesday to go through 5-4 on aggregate.
IMAGES from the soccer matches played across European leagues over the weekend.
Holders Bayern Munich and nine-times winners Real Madrid will face each other in a mouthwatering Champions League semi-final this month with Atletico Madrid up against Chelsea.
Real Madrid captain Sergio Ramos performed another rescue act to wreck Napoli's brave comeback attempt and take the Champions League title-holders into the quarter-finals.
Luuk de Jong's first-half header gave Barcelona a 1-0 win at Mallorca
In his absence, the league champions have made a lacklustre start to the season, losing their opening game to Athletic Bilbao before taking just four points from fixtures against Real Betis and Osasuna.
Real Madrid paid more than 200 million euros ($227.76 million) to assemble their forward line of Cristiano Ronaldo, Gareth Bale and Karim Benzema, but the attacking trio failed them again in Wednesday's Champions League exit to Juventus.
Lionel Messi's double strike helped Barcelona scrape a 3-2 victory over Real Sociedad on Saturday to keep the pressure on La Liga leaders Real Madrid, who needed a brace from Isco to beat Sporting Gijon by the same scoreline.
News of all that's transpired on and off the football field
Diego Costa's season is getting better and better. The Atletico striker found the net again and took the Madrid team atop the La Liga table.
Barcelona's Sergi Roberto and Robert Lewandowski struck just before halftime to give the league leaders a 2-0 home win over lowly Cadiz on Sunday in their pursuit of a 27th Spanish title.
Cristiano Ronaldo and Lionel Messi will resume their perennial battle to be crowned the world's best footballer after they headed the shortlist of 30 players for the 2016 Ballon d'Or announced on Monday.
Atletico Madrid were handed a chance to avenge last season's Champions League final defeat by city rivals and record 10-times winners Real after the two sides were drawn together in the last eight on Friday. Paris St Germain and Barcelona were paired together having met in the group stage, with the French side winning in Paris and the Catalans coming out on top in Spain.
A Neymar double, a spectacular volley from Luis Suarez and a goal for Lionel Messi saw top of the table Barcelona's unstoppable strike force sweep aside Real Sociedad 4-0 in La Liga on Saturday.
Chelsea reached the Champions League quarter-finals with a 3-1 aggregate win against Galatasaray on Tuesday, with Real Madrid joining them in the last eight after thrashing Schalke 04 9-2 over two legs of their last-16 tie.
News of all that's transpired on and off the football field
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